Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Identifieur interne : 001010 ( Main/Exploration ); précédent : 001009; suivant : 001011Pharmacological modulation of autophagy enhances Newcastle disease virus-mediated oncolysis in drug-resistant lung cancer cells.
Auteurs : Ke Jiang ; Yingchun Li ; Qiumin Zhu ; Jiansheng Xu ; Yupeng Wang ; Wuguo Deng ; Quentin Liu ; Guirong Zhang [République populaire de Chine] ; Songshu MengSource :
- BMC cancer [ 1471-2407 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (), Chloroquine (pharmacologie), Embryon de poulet, Humains, Lignée cellulaire tumorale, Protéines associées aux microtubules (génétique), Résistance aux médicaments antinéoplasiques (), Sirolimus (pharmacologie), Souris, Souris nude, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Thérapie virale de cancers (), Transplantation tumorale, Tumeurs du poumon (), Tumeurs du poumon (anatomopathologie), Tumeurs du poumon (génétique), Virus de la maladie de Newcastle (), Virus oncolytiques ().
- MESH :
- anatomopathologie : Tumeurs du poumon.
- génétique : Protéines associées aux microtubules, Tumeurs du poumon.
- pharmacologie : Chloroquine, Sirolimus.
- Animaux, Autophagie, Embryon de poulet, Humains, Lignée cellulaire tumorale, Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Techniques de knock-down de gènes, Tests d'activité antitumorale sur modèle de xénogreffe, Thérapie virale de cancers, Transplantation tumorale, Tumeurs du poumon, Virus de la maladie de Newcastle, Virus oncolytiques.
English descriptors
- KwdEn :
- Animals, Autophagy (drug effects), Cell Line, Tumor, Chick Embryo, Chloroquine (pharmacology), Drug Resistance, Neoplasm (drug effects), Gene Knockdown Techniques, Humans, Lung Neoplasms (genetics), Lung Neoplasms (pathology), Lung Neoplasms (therapy), Mice, Mice, Nude, Microtubule-Associated Proteins (genetics), Neoplasm Transplantation, Newcastle disease virus (drug effects), Oncolytic Virotherapy (methods), Oncolytic Viruses (drug effects), Sirolimus (pharmacology), Xenograft Model Antitumor Assays.
- MESH :
- chemical , genetics : Microtubule-Associated Proteins.
- chemical , pharmacology : Chloroquine, Sirolimus.
- drug effects : Autophagy, Drug Resistance, Neoplasm, Newcastle disease virus, Oncolytic Viruses.
- genetics : Lung Neoplasms.
- methods : Oncolytic Virotherapy.
- pathology : Lung Neoplasms.
- therapy : Lung Neoplasms.
- Animals, Cell Line, Tumor, Chick Embryo, Gene Knockdown Techniques, Humans, Mice, Mice, Nude, Neoplasm Transplantation, Xenograft Model Antitumor Assays.
Abstract
Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/FMW virotherapy of drug-resistant lung cancer cells.
DOI: 10.1186/1471-2407-14-551
PubMed: 25078870
Affiliations:
Links toward previous steps (curation, corpus...)
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Le document en format XML
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Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name></author><author><name sortKey="Zhang, Guirong" sort="Zhang, Guirong" uniqKey="Zhang G" first="Guirong" last="Zhang">Guirong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9 Lvshun Road South, Dalian 116044, China. zhang.lth@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9 Lvshun Road South, Dalian 116044</wicri:regionArea><wicri:noRegion>Dalian 116044</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Songshu" sort="Meng, Songshu" uniqKey="Meng S" first="Songshu" last="Meng">Songshu Meng</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25078870</idno><idno type="pmid">25078870</idno><idno 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cells.</title><author><name sortKey="Jiang, Ke" sort="Jiang, Ke" uniqKey="Jiang K" first="Ke" last="Jiang">Ke Jiang</name></author><author><name sortKey="Li, Yingchun" sort="Li, Yingchun" uniqKey="Li Y" first="Yingchun" last="Li">Yingchun Li</name></author><author><name sortKey="Zhu, Qiumin" sort="Zhu, Qiumin" uniqKey="Zhu Q" first="Qiumin" last="Zhu">Qiumin Zhu</name></author><author><name sortKey="Xu, Jiansheng" sort="Xu, Jiansheng" uniqKey="Xu J" first="Jiansheng" last="Xu">Jiansheng Xu</name></author><author><name sortKey="Wang, Yupeng" sort="Wang, Yupeng" uniqKey="Wang Y" first="Yupeng" last="Wang">Yupeng Wang</name></author><author><name sortKey="Deng, Wuguo" sort="Deng, Wuguo" uniqKey="Deng W" first="Wuguo" last="Deng">Wuguo Deng</name></author><author><name sortKey="Liu, Quentin" sort="Liu, Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name></author><author><name sortKey="Zhang, Guirong" sort="Zhang, Guirong" uniqKey="Zhang G" first="Guirong" last="Zhang">Guirong Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9 Lvshun Road South, Dalian 116044, China. zhang.lth@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, 9 Lvshun Road South, Dalian 116044</wicri:regionArea><wicri:noRegion>Dalian 116044</wicri:noRegion></affiliation></author><author><name sortKey="Meng, Songshu" sort="Meng, Songshu" uniqKey="Meng S" first="Songshu" last="Meng">Songshu Meng</name></author></analytic><series><title level="j">BMC cancer</title><idno type="eISSN">1471-2407</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Autophagy (drug effects)</term><term>Cell Line, Tumor</term><term>Chick Embryo</term><term>Chloroquine (pharmacology)</term><term>Drug Resistance, Neoplasm (drug effects)</term><term>Gene Knockdown Techniques</term><term>Humans</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (pathology)</term><term>Lung Neoplasms (therapy)</term><term>Mice</term><term>Mice, Nude</term><term>Microtubule-Associated Proteins (genetics)</term><term>Neoplasm Transplantation</term><term>Newcastle disease virus (drug effects)</term><term>Oncolytic Virotherapy (methods)</term><term>Oncolytic Viruses (drug effects)</term><term>Sirolimus (pharmacology)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autophagie ()</term><term>Chloroquine (pharmacologie)</term><term>Embryon de poulet</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Protéines associées aux microtubules (génétique)</term><term>Résistance aux médicaments antinéoplasiques ()</term><term>Sirolimus (pharmacologie)</term><term>Souris</term><term>Souris nude</term><term>Techniques de knock-down de gènes</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Thérapie virale de cancers ()</term><term>Transplantation tumorale</term><term>Tumeurs du poumon ()</term><term>Tumeurs du poumon (anatomopathologie)</term><term>Tumeurs du poumon (génétique)</term><term>Virus de la maladie de Newcastle ()</term><term>Virus oncolytiques ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Microtubule-Associated Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Drug Resistance, Neoplasm</term><term>Newcastle disease virus</term><term>Oncolytic Viruses</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines associées aux microtubules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Oncolytic Virotherapy</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term><term>Sirolimus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Chick Embryo</term><term>Gene Knockdown Techniques</term><term>Humans</term><term>Mice</term><term>Mice, Nude</term><term>Neoplasm Transplantation</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Embryon de poulet</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Résistance aux médicaments antinéoplasiques</term><term>Souris</term><term>Souris nude</term><term>Techniques de knock-down de gènes</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Thérapie virale de cancers</term><term>Transplantation tumorale</term><term>Tumeurs du poumon</term><term>Virus de la maladie de Newcastle</term><term>Virus oncolytiques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharmacologically modulating autophagy could enhance oncolytic Newcastle disease virus (NDV) strain NDV/FMW virotherapy of drug-resistant lung cancer cells.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Deng, Wuguo" sort="Deng, Wuguo" uniqKey="Deng W" first="Wuguo" last="Deng">Wuguo Deng</name><name sortKey="Jiang, Ke" sort="Jiang, Ke" uniqKey="Jiang K" first="Ke" last="Jiang">Ke Jiang</name><name sortKey="Li, Yingchun" sort="Li, Yingchun" uniqKey="Li Y" first="Yingchun" last="Li">Yingchun Li</name><name sortKey="Liu, Quentin" sort="Liu, Quentin" uniqKey="Liu Q" first="Quentin" last="Liu">Quentin Liu</name><name sortKey="Meng, Songshu" sort="Meng, Songshu" uniqKey="Meng S" first="Songshu" last="Meng">Songshu Meng</name><name sortKey="Wang, Yupeng" sort="Wang, Yupeng" uniqKey="Wang Y" first="Yupeng" last="Wang">Yupeng Wang</name><name sortKey="Xu, Jiansheng" sort="Xu, Jiansheng" uniqKey="Xu J" first="Jiansheng" last="Xu">Jiansheng Xu</name><name sortKey="Zhu, Qiumin" sort="Zhu, Qiumin" uniqKey="Zhu Q" first="Qiumin" last="Zhu">Qiumin Zhu</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Guirong" sort="Zhang, Guirong" uniqKey="Zhang G" first="Guirong" last="Zhang">Guirong Zhang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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